Regulates Mitophagy and Mitochondrial Function to Protect Against Alcohol - 1 induced Liver Injury and Steatosis in Mice
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چکیده
Parkin Regulates Mitophagy and Mitochondrial Function to Protect Against Alcohol1 induced Liver Injury and Steatosis in Mice 2 3 Jessica A. Williams, Hong-Min Ni, Yifeng Ding, Wen-Xing Ding* 4 5 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical 6 Center, Kansas City, Kansas 66160, USA 7 8 9 10 11 12 *Correspondence to: Wen-Xing Ding, Ph.D., Department of Pharmacology, Toxicology and 13 Therapeutics, University of Kansas Medical Center, MS 1018 14 3901 Rainbow Blvd., Kansas City, Kansas 66160, Phone: 913-588-9813; Fax: 913588-7501, 15 Email: [email protected] 16 17 18 19 20
منابع مشابه
Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.
Alcoholic liver disease claims two million lives per year. We previously reported that autophagy protected against alcohol-induced liver injury and steatosis by removing damaged mitochondria. However, the mechanisms for removal of these mitochondria are unknown. Parkin is an evolutionarily conserved E3 ligase that is recruited to damaged mitochondria to initiate ubiquitination of mitochondrial ...
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TO THE EDITOR: In a recent paper in the American Journal of Physiology Gastrointestinal and Liver Physiology, Williams et al. (21) investigated the role of Parkin against alcohol-induced liver injury in wild-type (WT) and Parkin knockout (KO) mice using two methods of alcohol administration: acute-binge and Gao-binge. They found that Parkin protects against alcoholinduced liver injury and steat...
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Introduction: In many cultures fasting is recommended as a way to protect and promote health. However, there are few studies on the effects of fasting on organ function and resistance to toxic agents such as drugs. This study was conducted to investigate the effect of short-term periodic fasting on the acetaminophen hepatotoxic effects in mice. Methods: In this...
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تاریخ انتشار 2015